conventional cancer treatment

SIDE-EFFECTS OF CHEMOTHERAPY INTERVENTION

Are you being talked into chemotherapy?

What your doctors won’t tell you….

The side-effects of chemotherapy drugs are generally categorized in the medical studies as follows, according to their ‘site of action’ :

1. DIGESTIVE UPSETS (NAUSEA, VOMITING, ANOREXIA, STOMATITIS, DIARRHOEA, ETC.):

SCHEIN, P.S., MACDONALS, J.S., WATERS, C., HAIDAK,D., Nutritional complications of cancer and its treatment, Semin. Oncol., Dec. 1975; 2 (4): 337-347; DREIZEN, S., Stomatotoxic manifestations of cancer chemotherapy, J. Prosthet. Dent., Dec. 1978; HYSON, E.A., BURRELL, M., TOFFLER, R., Drug-induced gastro intestinal disease, Gastrointest. Radiol., 20 Dec. 1977; 2 (3): 183-212; OHNOMA, T., HOLLAND, J.F., Nutritional consequences of cancer chemotherapy and immunotherapy, Cancer Res., July 1977, 37 (7 Pt 2): 2395-2406; N.N., Cancer chemotherapy the inbuilt deterrent, Br. Med. J., 24 Nov. 1979; 2 (6201): 1312-1313; SCHUM, C.A., IZUTSU, K.T., MOLBO, D.M., TRUELOVE, E.L., GALLUCCI,B., Changes in salivary buffer capacity in patients undergoing cancer chemotherapy, J. Oral. Med., Jul-Sept., 1979; 34 (3): 76-80; SCOGNA, D.M., SMALLEY, R.V., Chemotherapy-induced nausea and vomiting, Am J. Nurs., Sept. 1979; 79 (9): 1562-1564; KENNEDY, M., PACKARD, R., GRANT, M.M., PADILLA, G.V., Chemotherapy related nausea and vomiting: a survey to identify problems and interventions, Oncol. Nurs. Forum, Winter 1981; 8 (1): 19-22.

2. AFFECTIONS OF THE SKIN AND MUCUOUS MEMBRANE (ALL SORTS OF AFFECTIONS, NAIL DAMAGE, ALOPECIA, ETC.):

NIXON, D.W, Alterations in nail pigment with cancer chemotherapy, Arch. Intern. Med., Oct. 1976; 136 (10): 1117-1118; DREIZEN, S., BODEY, G.P., RODRIGUEZ, V., McCREDIE, K.B., Cutaneous complications of cancer chemotherapy, Postgrad. Med., Nov. 1975; 58 (6): 150-158; BARAN, R., Pigmentation of the nail (chromonynchia), J. Dermatol. Surg. Oncol., Mar. 1978; 4 (3): 250-254; GAUCI, L., SERROU, B., Changes in hair pigmentation associated with cancer chemotherapy, Cancer Treat. Rep., Jan. 1980; 64 (1): 193.

3. HAEMATOPOIETIC ALTERATION (IMMUNO-DEPRESSION, BLOOD COMPOSITION ALTERATION, ETC.):

JEDRZEJCZAK, W.W., SIEKIERZYNSKI, M., CZARNECKI, C., DZIUK, E., Patterns of changes in peripheral blood composition in the course of combination chemotherapy of cancer, Strahlentherapie, Nov. 1976; 152 (5): 469-476; BODEY G.P., RODRIGUEZ, V., McCREDIE, K.B., FREIREICH, E.J., Neutropenia and infection following cancer chemotherapy, Int. J. Radiat. Oncol. Biol. Phys., Jan. - Feb. 1976; 1 (3-4): 301-304; VAN DER HOEVEN, L., CHANG, J.C., Disorders of granulocytes induced by toxic agents, Ann. Clin. Lab. Sci., Sept. - Oct. 1976; 6 (5): 415-422; TATTERSHALL, M.H., Aggressive cancer treatment and its role in predisposing to infection, Eur. J. Cancer, Aug. 1975; 11 Suppl.: 9-19; RENOUX, M., BERNARD, J.F., TORRES, M., SCHLEGEL, N., AMAR, M., LOPEZ, M., BOIVIN, P., Erythrocyte abnormalities induced by chemotherapy and radiotherapy: induction of pre leukaemic state., Scand. J. Hematol., Oct. 1978; 21 (4): 323-332; FERRARO, E.F., Implications of anti neoplastic therapy, Dent. Surv., Febr. 1978; 54 (2): 32-33; MASON, B.A., KLUG, P.P., COHEN, P., Bone marrow necrosis during chemotherapy for lymphoma, J.A.M.A., 20 Mar. 1978; 239 (12): 1158; BADHURI, S., RASHE, H., KÖHLE, W., DIETRICH, M., Blutgerinnungsstudien bei Patienten mit akuter Leukämie vor und nach zytostatischer Chemotherapie, Verh. Dtsch. Ges. Inn. Med., 17-21 Apr. 1977; 83: 1142-1144; KAKISHITA, E., YOSHIMURA, S., Influence of anti cancer chemotherapy on haemostatic mechanism (Japanese), Rinsho Byori, Dec. 1977, 25 (12): 985-991; NERI, A., BRUGIATELLI, M., COMIS, M., IACOB, P., NOBILE, F., PACIUCCI, P.A., LOMBARDO, V.T., Severe acute hyperkalaemia following chemotherapy, Haematologica (Pavia), Jun. 197 ***; 62 (3): 331-332; KREPLER, P., Infections in children with malignant disease, Wien. Klin. Wochenschr., 9 Nov. 1979; 91 (21): 707-71 *** ; RYBALBA, A.M., Prevention and treatment of haemapoietic disorders during the chemotherapy of malignant ovarian tumours (Ukranian), Pedriatr. Akush. Ginekol., Sept. - Oct. 1979; (5): 45-46; ETIEMBLE, J., BERNARD, J.F., PICAT, C., BELPOMME, D., BOIVIN, P., Red blood cell enzyme abnormalities in patients treated with chemotherapy, Br. J. Haematol., Jul. 1979; 42 (3): 391-398: HAROUSSEAU, J.L., TOBELEM, G., SCHAISON, G., JACQUILLAT, C., Leucémies aigues lymphoblastiques hyperleucocytaires: problèmes d’urgence au cours du traitement initial, Nouv. Presse Méd., 19 May 1979; 8 (22): 1827-1830; LY, B., SOLHEIM, B.G., SKAR, A.G., Granulocytopenia and infections during induction therapy of acute leukaemia (Norwegian), Tidsskr. Nor. Laegeforen, Febr. 1981; 101 (6): 379-386.

4. AFFECTION OF THE REPRODUCTIVE ORGANS (STERILITY, IMPOTENCE, AZOOSPERMIA, AMENORRHEA, GYNECOMASTIA, ETC.):

RUSSEL, J.A., POWLES, R.L., OLIVER, R.T., Conception and congenital abnormalities after chemotherapy of acute myelogenous leukaemia in two men, Br. Med. J., 19 Jun. 1976; 1 (6024): 1508; SIRIS, E.S., LEVENTHAL, B.G., VAITUKAITIS, J.L., Effects of childhood leukaemia and chemotherapy on puberty and reproductive function in girls, N. Engl. J. Med., 20 May 1976; 294 (21): 1143-1146; ASBJORNSEN, G., MOLNE, K., KLEPP, O., AAKVAAG, A., Testicular function after combination chemotherapy for Hodgkin’s disease, Scand. J. Haematol., Jan. 1976; 16 (1): 66-69; DI LIBERTI, J.H., Teratogenesis and chemotherapy, Ann. Intern. Med., Nov. 1974; 81 (5): 709; SUTCLIFFE, S.B., Cytotoxex chemotherapy and gonadal function in patients with Hodgkin’s disease, J.A.M.A., 26 Oct. 1979; 242 (17): 1898-1899; CHAPMAN, R.M., SUTCLIFFE, S.B., MALPAS, J.S., Cytotoxic-induced ovarian failure in Hodgkin’s disease. Effects on sexual function, J.A.M.A., 26 Oct. 1979; 242 (17): 1882-1884; GLASS, A.R., BERENBERG, J., Gynecomastia after chemotherapy for lymphoma, Arch. Intern. Med., Sept. 1979; 139 (9): 1048-1049; RUSTIN, G.J., BAGSHAWE, K.D., NEWLANDS, E.S., BEGENT, R.H., Cytotoxic drugs and sterility, Lancet, 13 Jun. 1981; 1 (8233): 1316; THORNELDE, W.F., Cytotoxic-induced ovarian failure in Hodgkin’s disease, J.A.M.A., 1 Aug. 1980; 244 (5): 435.

5. RENAL AND LIVER DAMAGE:

JAYABOSE, S., SHENDE, A., LANZKOWSKY, P., Hepatotoxicity of chemotherapy following nephrectomy and radiation therapy for right-sided Willms tumour, J. Pediatr., May 1976; 88 (5): 898; KANFER, A., ROLAND, J., CHATELET, F., RICHET, G., Insuffisance rénale aigue hyperphosphatémique au cours d’un lymphosarcome, J. Urol. Nephrol., (Paris), Apr. - May 1979; 85 (4-5): 337.

6. IMPAIRMENT OF THE OSSEOUS (SKELETAL) SYSTEM:

IHDE, D.C., DEVITA, V.T., Osteonecrosis of the femoral head in patients with lymphoma treated with intermittent combination chemotherapy, Cancer, Nov. 1975; 36 (5): 1585-1588.

7. PULMONARY DISEASES:

KÜHBÖCK, S., Lungenfibrosen nach Behandlung mit Zytostatika, Wien. Med. Wochenschr., 1 Oct. 1976; 126 (40): 568-570; CAUBARRERE, I., Les pneumopathies infectueuses au cours de la chimiothérapie des hémopathies malignes, Rev. Prat., 21 May 1976; 26 (29): 2051-2060; SIZOD, W., WOLVIUS, G.G., Pneumocystis-pneumonie als complicatie bij cytostatische therapie, Nederl. Tijdschr. Geneeskunde, 6 Mar. 1976; 120 (10): 418-424; SAUER, E., GULLOTTA, U., FINK, U., Akute beidseitige Lungeninfiltration als Komplikation der Zytostatischen Therapie, Dtsch. Med. Wochenschr., 10 Oct. 1975; 100 (41): 2098-2101; OKITA, H., ITO, K., TAKETOMI, Y., FUJIMURA, K., KURAMOTO, A., Four patients with leukaemia who showed especially a typical type of interstitial pneumonia, probably caused following the administration of anti-leukaemic drugs (Japanese), Jpn. J. Clin. Hematol., 30 Jul. 1974; 15 (7): 764-773; HERMANSKY, F., BENESOVA, E., CHMEL, J., JIRAK, A., Pulmonary complications caused by cytostatic treatment (Czech), Vnitr. Lek., Jun. 1977; 23 (7): 695-701; DEMETER, S.L., AHAMD, M., TOMASHEKSKI, J.F., Drug-induced pulmonary disease, Cleve. Clin. Q., Fall 1979; 46 (3): 113-124; ZHU, G.Y., Acute pulmonary edema during chemotherapy of late stage tumors (Chinese), Chung Hua Chieh Ho Ho Hu Hsi Hsi Chi Ping Tsa Chih, Dec. 1980; 3 (4): 201-202.

8. MUTAGENIC (CANCER-CAUSING) CHANGES:

MAJSKY, A., JAKOUBKOVA, J., ABRAHAMOVA, J., Chemotherapy one of the causes of transient loss of HLA antigens and lymphocyte poly-reactivity in patients with blood diseases and malignancies, J. Immunogenet., Dec. 1976; 3 (6): 429-433; ROSS, G.T., Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms, Cancer, Feb. 1976; 37 (2 Suppl.): 1043-1047; POLEKSIC, S., YEUNG, K.Y., Rapid development of keratoancanthoma and accelerated transformation into squamous cell carcinoma of the skin: a mutagenic effect of polychemotherapy in a patient with Hodgkin’s disease, Cancer, Jan. 1978; 41 (1): 12-16; SCHAISON, G., JACQUILLAT, C., AUCLERC, G., WEIL, M., Les risques foeto-embryonnaires des chimiothérapies, Bull. Cancer (Paris), 1979; 66 (2): 165-170; SAKALOVA, A., BENKO, J., IZAKOVIC, V., Anti tumorous therapy and its consequences upon gravidity and foetus (Slovakian), Cesk. Gynekol., May 1979; 44 (4): 272-276; SCHADER, A.I., Teratogenic effects of anti leukaemia chemotherapy, Arch. Intern. Med., Mar. 1981; 141 (4): 514-515; KAEMPFER, S.H., The effects of cancer chemotherapy on reproduction: a review of the literature, Oncol. Nurs. Forum, Winter 1981; 8 (1): 11-18.

9. CANCER-PRODUCING SIDE-EFFECTS:

HAQUE, T., LUTCHER, C., FAGUET, G., TALLEDI, O., Chemotherapy-associated acute myelogenous leukaemia and ovarian carcinoma, Am. J. Med. Sci., Sept. - Oct. 1976; 272 (2): 225-228; JOCHIMSEN, P.R., PEARLMAN, N.W., LAWTON, R.L., Pancreatic carcinoma as a sequel to therapy of lymphoma, J. Surg. Oncol., 1976; 8 (6): 461-464; SEIDENFELD, A.M., SMYTHE, H.A., OGRYZLO, M.A., UROWITZ, M.B., DOTTEN, D.A., Acute leukaemia in rheumatoid arthritis treated with cytotoxic agents, J. Rheumatol., Sept. 1976; 3 (3): 295-304; ROBERTS, M.M., Acute leukaemia after immunosuppressive therapy, Lancet, 9 Oct. 1976; 2 (7989): 768-770; KUIS, W., DE KRAKER, J., KUIJTEN, R.H., DONCKERWOLCKE, R.A., VOUTE, P.A., Acute lymphoblastic leukaemia after treatment of nephrotic syndrome with immunosuppressive drugs, Helv. Paediatr. Acta, Jun. 1976; 31 (1): 91-95; NAESS, K., Cancer of the pancreas chemically induced. Can drugs play a role? (Norwegian), Tidsskr. Nor. Laegeforen, 10 Jun. 1976; 96(16): 949; STECHMILLER, B., WIERNIK, P.H., SHIN, M., SATTERFIELD, J., Metastatic teratocarcinoma following chemotherapy. Maturation to a mass pathologically indistinguishable from a mediastinal enteric cyst, Chest, May 1976; 69 (5): 697-700; JAFFE, N., Late side-effects of treatment: skeletal, genetic, central nervous system and oncogenic, Pediatr. Clin. N. Am., Feb. 1976; 23 (1): 233-244; MEADOWS, A.T., D’ANGIO, G.J., EVANS, A.E., HARRIS, C.C., MILLER, R.W., MIKE, V., Oncogenesis and other late effects of cancer treatment in children, Radiology, Jan. 1975; 114 (1): 175-180; SCHWARZ, J.H., CANELLOS, G.P., YOUNG, R.C., DEVITA, V.T. Jr., Meningeal leukaemia in the blastic phase of chronic granulocytic leukaemia, Am. J. Med., Dec. 1975, 59 (6): 819-829; TERRACINI, B., Il ruolo di alcuni farmaci nell’ezioologia dei tumori delle vie urinarie, Cancro, 1973; 26 (3): 185-188; LI, F.P., CASSADY, J.R., JAFFE, N., Risk of second tumours in survivors of childhood cancer, Cancer, Apr. 1975: 35 (4): 1230-1235; CARTER, S.K., Second tumours complicating cancer therapy, Haematol. Bluttransfus., 1978; 22: 41-44; BOIVIN, P., Les leucémies induites par la radiothérapie ou par la chimiothérapie peuvent-elles êtres prévues? Nouv. Presse Méd., 9 Sept. 1979; 7 (29): 2533-2534; LEGLER, F., Karzinogenese durch Schadstoffe aus der Umwelt, Pharmaka und Ernährungsgewohnheiten, Oeff. Gesundheitswes., Oct. 1978; 40 (10): 653-662; SCHULER, D., Iatrogenic carcinogenesis (Hungarian), Orv. Hetil., 10 Sept. 1978; 119 (37): 2239-2243; ROSNER, F., Is chemotherapy carcinogenic?, Cancer, Jan. Feb. 1978; 28 (1): 57-59; PENN, I., Malignancies associated with immunosuppressive or cytotoxic therapy, Surgery, May 1978; 83 (5): 492-502; NIEWEG, H.O., Iatrogene leukaemie, Nederl. Tijdschr. Geneesk., 25 Mar. 1978; 122 (12): 398-401; MULDER, N.H., HOUWEN, B., Behandelen en vooruitzien. Acute leukaemie na behandeling van een andere kwaadaardige ziekte, Nederl. Tijdschr. Geneesk., 25 Mar. 1978; 122 (12): 385-399; ERSKINE, J.G., WANG, I., HUTTON, M.M., Chronic granulocytic leukemia developing upon a follicular lymphoma, Br. Med. J., 19 Nov. 1977; 2 (6098): 1329; CADMAN, E.C., CAPIZZI, R.L., BERTINO, J.R., Acute non-lymphocytic leukaemia: a delayed complication of Hodgkin’s disease therapy: analysis of 109 cases, Cancer, Sept. 1977; 40 (3): 1280-1296; CHABNER, B.A., Second neoplasm a complication of cancer chemotherapy, N. Engl. J. Med., 28 Jul. 1977, 297 (4): 213-215; KURTIDES, E.S., Breast cancer, chemotherapy and second malignant neoplasms, J.A.M.A., 4 Jul. 1977; 238 (1): 28-29; WOLF, M.M., COOPER, I.A., DING, J.C., Hodgkin’s disease terminating in acute leukaemia: a report of seven cases, Austr. N. Z. J. Med., Aug. 1979; 9 (4): 398-402; KAHN, M.F., ARLET, J., BLOCH-MICHEL, H., CAROIT, M., CHAOUAT, Y., RENIER, J.C., Leucémies aigues après traitement par agents cytotoxiques en rhumatologie. 19 observations chez 2006 patients, Nouv. Presse Méd., 14 Apr. 1979; 8 (17): 1393-1397; PENN, I., Leukaemias and lymphomas associated with the use of cytotoxic and immunosuppressive drugs, Cancer Res., 1979; 69: 7-13; JOUET, J.P.,HUART, J.J., BAUTERS, F., GOUDEMAND, M., Leucémies aigues complicant la maladie de Hodgkin. Cinq nouvelles observations, Nouv. Presse Méd., 17 Feb. 1979; 8 (8): 613-614; DANO, K., FORCHHAMMER, J., Carcinogenesis and drugs (Danish), Ugeskr. Laeger., Aug. 1981; 143 (35): 2246-2247; FARBER, E., Chemical carcinogenesis, N. Engl. J. Med., 3 Dec. 1981; 305 (23): 1379-1389; STEWART, A.L., WILKINSON, P.M., Rapid onset of acute myeloid leukaemia following radiotherapy and chemotherapy for metastatic seminoma of the testis, J. Cancer Res. Clin. Oncol., 1981; 100 (1): 109-111; HOOVER, R., FRAUMENI, J.F., Jr., Drug-induced cancer, Cancer, 1 Mar. 1981; 47 (5 Suppl.): 1071-1080; BLANC, A.P., GASTAUT, J.A., SEBAHOUN, G., DALIVOUST, P., MURISASCO, A., CARCASSONNE, Y., Naissance d’une leucémie aigue au décours d’un traitement immunosupprésseur par le chlorambucil. Une observation, Nouv. Presse Méd., May 1981; 10 (21): 1717-1719; CORDIER, J.F., TOURAINE, R., Cancers épidermoides du poumon chez un patient traité pour cancer aplasique à petites cellules. La chimiothérapie favorise-t-elle le développement de cancers d’un autre type histologique?, Nouv. Presse Méd., 9 May 1981; 10 (21): 1713-1716; ASBORNSEN, G., GODAL, H.C., MYHRE, K., Acute myelogenous leukaemia after cytostatic therapy in breast cancer (Norwegian), Tidsskr. Nor. Laegeforen, Feb. 1981; 101 (6): 387-388; PENN, I. Immunosuppression and skin cancer, Clin. Plast. Surg., Jul. 1980, 7 (3): 361-368; CHAN, K.W., MILLER, D.R., TAN, C.T., Osteosarcoma and acute myeloblastic leukaemia after therapy for childhood Hodgkin’s disease - a case report, Med. Pediatr. Oncol., 1980; 8 (2): 143-149; MAHOMED, Y., MANDEL, M.A., CRAMER, S.F., MICHEL, B., Squamous cell carcinoma arising in pemphigus vulgaris during immunosuppressive therapy, Cancer, 15 Sept. 1980; 46 (6): 1374-1377; DOHY, H., GENOT, J.Y., IMBERT, M., D’AGAY, M.F., SULTAN, C., Myelodysplasia and leukaemia related to chemotherapy and/or radiotherapy: a haematological study of 13 cases. Value of macrocytosis as an early sign of bone marrow injury, Clin. Lab. Haematol., 1980, 2 (2): 111-119.

10. IMPAIRMENT OF THE CENTRAL NERVOUS SYSTEM:

SHERKOW, L.H., Chemotherapeutic neurotoxicity on brain scintigraphy, Clin. Nucl. Med., Oct. 1979; 4 (10): 439-440.

11. CARDIOTOXICITY:

KAYE, S.B., IKRAM, H., Acute cardiac pain and electrocardiographic changes following cytotoxic treatment for metastatic carcinoma, Clin. Oncol., Sept. 1976; 2 (3): 215-218; WEINSTEIN, P., GREENWALD, E.S., GROSSMAN, J., Unusual cardiac reaction to chemotherapy following mediastinal irradiation in a patient with Hodgkin’s disease, Am. J. Med., Jan. 1976; 60 (1): 152-156; APPELBAUM, F., STRAUCHEN, J.A., GRAW, R.G. Jr., SAVAGE, D.D., KENT, K.M., FERRANS, V.J., HERZIG, G.P., Acute lethal carditis caused by high-dose combination chemotherapy. A unique clinical and pathological entity, Lancet, 10 Jan. 1976; 1 (7950): 58-62; GHIONE, M., Effetti tossici dei farmaci antitumorali sul sistema cardiovascolare, Recent Prog. Med. (Roma), Oct. 1977; 63 (4): 382-410; SZABO, G., KOVACS, A., Intra-arterial chemotherapy of head and neck tumours, Acta Chir. Acad. Sci. Hung., 1979; 20 (1): 49-55; GARIMOLDI, M., PIAZZA, E., BERTELLO, C., RUGGERI, P.R., LIBRETTI, A., Effetto della chemioterapia antiblastica su alcuni parametri cardiologice, Boll. Soc. Ital. Cardiol., 1978; 23 (10): 1785-1790.

12. MISCELLANEA:

Hansen SW; Helweg-Larsen S; Trojaborg W, Long-term neurotoxicity in patients treated with cisplatin, vinblastine, and bleomycin for metastatic germ cell cancer, J Clin Oncol (UNITED STATES) Oct 1989 7 (10) p1457-61;Eifel PJ; McClure S , Severe chemotherapy-induced recall of radiation mucositis in a patient with non-Hodgkin’s lymphoma of Waldeyer’s ring [letter], Int J Radiat Oncol Biol Phys Oct 1989 17 (4) p907-8; Tsatsoulis A; Shalet SM; Robertson WR; Morris ID; Burger HG; De Kretser DM, Plasma inhibin levels in men with chemotherapy-induced severe damage to the seminiferous epithelium., Clin Endocrinol (Oxf) (ENGLAND) Dec 1988 29 (6) p659-65; Ocular complications after intracarotid BCNU for intracranial tumors, Acta Ophthalmol (Copenh) Feb 1989 67 (1) p83-6; Gerasimova MM; Bogoslovskaia IA; Karcharova SV; Litovskaia AV, Professional diseases caused by the action of antibiotics, Vrach Delo (USSR) May 1989 (5) p109-12; Cartei G; Ceschia T; Marsilio P; Clocchiatti L; Fasola G; Morandini G; Galletti D; Sibau A, Effectiveness and toxicity of “BELD” polychemotherapy in advanced malignant melanoma, Tumori (ITALY) Jun 30 1989 75 (3) p229-32; Mansi ML , Clear cell renal carcinoma in a pregnant DES-exposed patient, J Am Osteopath Assoc (UNITED STATES) Jul 1989 89 (7) p929-32; Williams F, Diethylstilboestrol exposure and testicular cancer [letter], Int J Epidemiol (ENGLAND) Jun 1989 18 (2) p462-3 ISSN: 0300-5771 Language: ENGLISH; Bressollette L; Swirsky H; Kernaleguen D; Carlhant D; Fauquert P; Le Bot MA; Baccino E; Riche C, Hepatitis during treatment with tamoxifen. 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Radiol Med (Torino) (ITALY) Jun 1989 77 (6) p626-30; Grasela TH Jr; Walawander CA; Welage LS; Wing PE; Scarafoni DJ; Caldwell JW; Noguchi JK; Schentag JJ , Prospective surveillance of antibiotic-associated coagulopathy in 970 patients, Pharmacotherapy 1989 9 (3) p258-64; Rubin B; Palestine AG, Complications of corticosteroid and immunosuppressive drugs, Int Ophthalmol Clin (UNITED STATES) Fall 1989 29 (3) p159-71 ; Peiffert D; Bey P; Lederlin P; Conroy T; Witz F , Immediate hematological toxicity during combination chemotherapy- radiotherapy of Hodgkin’s disease, Bull Cancer (Paris) 1989 76 (4) p373-82; Szende B; Schally AV; Srkalovic G; Comaru-Schally AM; Wittliff JL , Adverse effect of tamoxifen with LHRH agonist on oestrogen-receptor-negative mammary carcinoma [letter] , Lancet (ENGLAND) Jul 22 1989 2 (8656) p222-3; Matsuura T; Nakabayashi H; Yanagisawa T; Yamazaki K; Watanabe R; Kameda H; Sakata A , Primary malignant lymphoma of the brain following immunosuppressive therapy of systemic lupus erythematosus, Nippon Naika Gakkai Zasshi (JAPAN) May 1987 76 (5) p730-5 ; Metzler M , Metabolism of some anabolic agents: toxicological and analytical aspects, J Chromatogr (NETHERLANDS) Apr 7 1989 489 (1) p11-21; Hirvonen HE; Salmi TT; Heinonen E; Antila KJ; Valimaki IA , Vincristine treatment of acute lymphoblastic leukaemia induces transient autonomic cardioneuropathy, Cancer Aug 15 1989 64 (4) p801-5; Wilkinson H , Dangers from methylprednisolone acetate therapy by intraspinal injection [letter], Arch Neurol (UNITED STATES) Jul 1989 46 (7) p721-2; Hillbertz-Nilsson K; Forsberg JG , Genotoxic effects of estrogens in epithelial cells from the neonatal mouse uterine cervix: modifications by metabolic modifiers, Teratogenesis Carcinog Mutagen (UNITED STATES) 1989 9 (2) p97-110; Gendron Y; Bronstein JA; Gras C; Boz P, Neuromuscular toxicity of colchicine. 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